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Through high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based molecular weight identification, standard molecular weight comparison, and characteristic HPLC profiles of the [ 3 H]proline and [ 3 H]BPC157 standards (Supplementary Figure S2), we speculated the structures of these six components and designated them as M1M6 (Table 10)
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Experimental vascular studies using isolated rat aorta preparations reported that BPC-157 modulated vasomotor tone and increased nitric oxide generation through activation of the SrcCaveolin-1endothelial nitric oxide synthase (eNOS) signaling pathway [3]
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