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Filtration and kidney reserve Creatinine and estimated GFR Cystatin C Urine albumin-to-creatinine ratio Urinalysis BUN and hydration context Acidbase and mineral balance Serum bicarbonate or carbon dioxide Sodium, potassium, chloride and magnesium Calcium and phosphorus Uric acid Dietary acid and alkali intake Methylation and oxidative burden SAM, SAH and SAM:SAH ratio Methionine and homocysteine Adenosine when available 8-OHdG and lipid peroxides Glutathione and transsulfuration markers Kidney detoxification strategies discussed by Dr

Why some people feel a "B12 boost" There's a reason B12 shots have a reputation for making people feel incredible, even when their levels aren't clearly deficient

Whether such combinations would behave additively, synergistically, or otherwise is a research question, not an established finding