2.6 In vitro cellular model: OGD/R in SH-SY5Y cells Human neuroblastoma SH-SY5Y cells were cultured in high-glucose Dulbeccos Modified Eagle Medium (DMEM) supplemented with 10% fetal bovine serum (FBS) (Gibco, Thermo Fisher Scientific, Waltham, MA, United States) and maintained in a 5% CO 2 incubator at 37C
Substances that raise GSH levels are being used with increasing frequency in the field of toxicology with considerable success
In particular, the disruption of melatonin chronobiology due to alterations in the light-dark schedule can significantly affect tumor etiopathology, by altering cell proliferation, cell death, and nutrient supply 160
Histone modifications: Affects histone acetyltransferases and deacetylases changing chromatin structure
Frontiers in Aging Neuroscience, 8 , 276.
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