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The 2,2-dimethyl substitution pattern on this ring occupies a lipophilic sub-pocket between TM2 and TM3 that is highly conserved in the GLP-1 receptor but differs in related class B GPCRs such as the glucagon and GIP receptors

The Takeaway The hottest drug class in the world just got even hotter, as the SUMMIT trial appears to show that tirzepatide could improve millions of HFpEF patients lives and outcomes a revelation that could lead to the drugs expanded approval, coverage, usage, and overall impact.