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Figure 4F illustrates that both targeting peptides significantly inhibited caspase-3 activity since decreasing fluorescence intensities of caspase-3 substrates were observed
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These modifications prevent IGF-1 LR3 from binding to IGF-binding proteins (IGFBPs), which normally deactivate regular IGF-1 within minutes
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384 However, canakinumab was also associated with a small increase in fatal infections such as sepsis (an infection in the blood), cellulitis, and pneumonia
However, its still important to be aware of potential interactions
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