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Over the past three decades (19902021), the global incidence of BPH has risen dramatically from ~6.5 million to 13.5 million new cases annually, underscoring the urgent need for effective treatment options (Box 1)

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Hancock BC, Carlson GT, Ladipo DD, Langdon BA, Mullarney MP

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10.3389/fnagi.2018.00411 115 KawasumiM.ChibaT.YamadaM.Miyamae-KanekoM.MatsuokaM.NakaharaJ.et al (2004)

Enhance growth factors BPC-157 peptide improves the receptivity of the growth hormone receptor and activates pathways critical for cell proliferation, tissue regeneration, and wound healing, especially in muscles and tendons