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Biomolecules 11(11):1575
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Exportin-1 (XPO1) Inhibition Sequesters p53 from MDM2 and MDM4 and is Highly Synergistic with MDM2 Inhibition in Inducing Apoptosis in Wild-type p53 Acute Myeloid Leukemias
Yes, when administered in medical-grade formulations by trained professionals, IV therapy is safe and well-tolerated
Targeting BCL-XL and BCL-2 by PROTAC 753b effectively eliminates AML cells and enhances efficacy of chemotherapy by targeting senescent cells
However, theyre not the ideal solution for everyone
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