Wang, Z.-X
Defense Against Oxidative Stress NAD+ supports antioxidant systems by aiding enzymes like glutathione reductase to regenerate glutathione, a key antioxidant that protects cells from oxidative damage
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The patient followed a traditional KD (70% fat, 25% protein, and 5% carbohydrates) for 24 weeks
Together, they model collagen and elastin synthesis, angiogenesis, and wound-healing dynamics
27-34 Of note, several trials in the PIONEER program used two estimands to further distinguish their analyses: 1) a treatment-policy estimand, which used data collected at the end of the study period (e.g., week 26 or 52) in the analysis regardless of treatment discontinuation or use of rescue medication