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Sleep Disorders Obstructive sleep apnea (OSA) represents a significant clinical breakthrough for GLP-1 RAs in sleep medicine, culminating in the historic FDA approval of tirzepatide (Zepbound) on December 20, 2024, as the first medication specifically indicated for moderate-to-severe OSA in adults with obesity [154]

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Age, activity level, and concurrent medications can shift this window further, which is why personalized medical supervision during dose adjustment remains essential