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Furthermore, imatinib induces ferroptosis in GIST by upregulating STUB1, which promotes K191 site-specific ubiquitination and degradation of GPX4, thereby disrupting the antioxidant defense, triggering lipid peroxidation, and leading to iron accumulation

The alpha variant infection did not induce any significant different risk profiles between adults and children groups

Glutathione is a relatively sensitive molecule

Glutathione Pathways and Individual Genetic Predispositions Glutathione synthesis and metabolism depend on genes encoding key enzymes, including GCLC, GCLM, and GSS