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In the PNA group, altered patterns of protein expression were also observed, with proteins such as CPOX and DPF2 being downregulated, while AMT and GSTM3 were upregulated (Fig

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Along with the RPE cells high metabolic demand mentioned previously, which depends on free iron as an imperative cofactor and produces considerable amounts of ROS, these findings firmly correlate ferroptosis with RPE cell death

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