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They are produced intracellularly in several stages: stages I and II include unmelanized immature premelanosomes in the middle of the melanocyte, whereas stages III and IV contain melanized melanosomes migrating to the outer edge of the cell through the dendrites 31

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doi: 10.3760/cma.j.cn311282-20220416-00234 60 SharmaD.ShastriS.SharmaP

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Shaking the vial vigorously rather than gently swirling can denature the peptide structure and create excessive foam, making accurate dose measurement difficult and potentially reducing medication potency