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Can use continuously or cycle 12 weeks on, 4 weeks off

J Biol Chem 279: 2593525938 Acknowledgements We thank The Wellcome Trust and the Biotechnology and Biological Sciences Research Council for financial support

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The increase of Hcy under metformin is likely linked to perturbances to the metabolism of vitamin B12 and may be more evident in obese PCOS [6]