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n = 510 mice (PDF 41 kb) Metformin treatment improves glucose tolerance in mice given the GLP1R antagonist exendin(9-39)

and (2) explore whether this combination would engender minor adverse effects on blood glucose metabolism, lipid levels, blood pressure levels, and renal and hepatic function

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Activation of Y1R results in osteoclast formation, negatively impacting bone maintenance, while activation of Y2R influences bone remodeling by modulating the activity of the sympathetic nervous system