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Perifollicular capillaries regress as the follicle shrinks, starving remaining cells of oxygen and nutrients

Mild gastrointestinal symptoms have been reported in some cases

In in vitro cell experiments using 3T3L1 preadipocytes as a model, treatment with NNMTi significantly reduced preadipocyte differentiation efficiency and markedly downregulated the expression of adipocyte markers (such as PPAR and C/EBP) in a dosedependent manner

It lasts longer in the body, so patients need it less often

In these situations, patients may have high B12 on blood work but still exhibit neurological symptoms of deficiency (tingling, numbness, cognitive changes)

Preclinical studies often require different dosing amounts depending on the administration route