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This was published in the New England Journal of Medicine: About 16.6 % average weight loss in participants who remained on treatment for 64 weeks

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2022 Aug 17;13 doi: 10.3389/fendo.2022.945609

In renal failure, perturbed intestinal microorganisms produce several metabolic products that can have an influence on the kidneys, including indoxyl sulfate, trimethylamine N-oxide, phenylacetylglutamine, and p-cresyl sulfate