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Liselotte van Bloemendaal's 2014 imaging work showed that GLP-1 receptor activation specifically attenuates the reward system's response to food cues, the neurobiological basis of what patients call the quieting of "food noise" (van Bloemendaal et al., 2014)

The FDA has also raised concerns about dosing errors, contamination, impurities and inconsistent ingredients in compounded GLP-1 drugs

doi: 10.1016/j.cbi.2013.02.006

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However, general guidelines are as follows: For Deficiency Treatment : Weekly shots for the first month, followed by monthly maintenance injections