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Cost, accessibility, and decades of safety data all support this approach unless specific risk factors point toward starting differently

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Estimations for the forecast period 2028

This triple mechanism of action distinguishes retatrutide from existing approved agents such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 receptor agonist)

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Maintaining gradual, well-paced weight loss and incorporating resistance training protects tissues and muscle tone, Sivaraman noted