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To exclude that the small spectral changes reflected just a partial glutathionylation, we performed electrophoretic mobility shift assays (Fig

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Regarding treatment strategies, it is suggested that the marked decrease in GPx1 expression may be the major mechanism of tumor sensitization to anthracyclines [93] and that GPx1 can partially inhibit doxorubicin-induced cell death-related signaling in breast cancer by interfering with the activation of the sphingomyelin-ceramide pathway [85]

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Our MOTS-c benefits guide covers the broader applications of this peptide, and the MOTS-c dosage chart provides specific protocol information