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Consequently, Akt phosphorylation and protein synthesis follow through activation of mTOR, phosphorylation of the translation initiation factor 4E-binding protein 1 (4E-BP1) and the simultaneous release of the eukaryotic translation initiation factor 4E (eIF4E), as well as the activation of ribosomal protein S6 Kinase beta 1 (S6K1)