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Glucose and pyruvate tolerance in animals fed regular chow Mice were fasted for 6 h (07:3013:30 hours) and then given metformin or vehicle (0.5% [wt/vol.] methylcellulose) 1 h prior to glucose or pyruvate administration

Carnitine is a friend in HFpEF and foe in HFrEF

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Archives of internal medicine 168, 598608 (2008)

Long-term randomized trials are scarce, and dose-response across diverse populations needs refinement

The biggest culprits are smoking, chronic poor sleep, sedentary lifestyle, and unmanaged chronic stress