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Published 2012 Jun 13

Clinical evaluation included daily assessment of lameness, defined as the inability of the rabbit to bear weight and maintain the typical flexion-extension cycle of the affected limb compared to the unaffected limb

Activation of nuclear factor-B (NF-B) induces transcription of target genes that primarily encode survival proteins (e.g., cellular FLICE-like inhibitory protein and inhibitor of apoptosis proteins) via formation of the complex I signalosome after binding to TNF receptor-1

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Researchers examine how this endogenous peptide affects sleep latency, sleep stage distribution, cortisol/corticosterone levels, and stress-induced sleep disturbances in experimental systems focused on sleep neuroscience and stress physiology

MacdonaldSBosioEShapiroNIBalmerLBurrowsSHibbsMet al