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Increased mitochondrial biogenesis (stimulates PGC-1 activation through stimulation of NO by guanylate cyclase) (144) and changes the muscle fiber type to a more oxidative phenotype when combined with the SIT [through the role of nuclear factor activated T cells (NFAT)calcineurin] (51, 145147)

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Ethics declarations The FR/FMG lab receives additional grant support from AstraZeneca, Eli Lilly and LGC for unrelated work