Evidence Gap Long-term (multi-year) outcomes data is still maturing
According to clinicians, sublingual administration bypasses both the gut and the liver, allowing glutathione to enter the bloodstream in its reduced (active) form, boosting the ratio of GSH to GSSG by 230 per cent, whereas oral glutathione supplementation is either reduced into simple amino acids during digestion or oxidised and hence, no longer stays active when swallowed
Vitamin C has been shown to restore intracellular glutathione and enhance its effects
There are a few exceptions
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Although it is somewhat more expensive than cheap cyanocobalamin supplements, there are clear benefits of hydroxocobalamin, and it matches the natural B12 profile found in foods