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Failure of this axis limits macrophage antioxidant and anti-inflammatory capacity and favors uncontrolled activation and hemophagocytosis, thereby lowering the threshold for MAS in SLE patients (67, 68)

Symptoms associated with exposure to inappropriate endotoxin levels may include fever, chills, myalgia (muscle pain), headache, nausea, vomiting, hypotension (low blood pressure), shock and death