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It Depends on the Individual Sustainability in weight loss doesnt just mean losing the weightit means keeping it off while improving overall health, energy, and metabolic function
Tamoxifen has an active metabolite, 4-OH-tamoxifen which easily crosses the blood-brain barrier (Lien et al., 1991), setting up its central action, while competitively inhibiting binding of estradiol to estrogen receptor alpha (ER-alpha) and estrogen receptor beta (ER-beta) (Novick et al., 2020), given the neuroprotective property of central estrogen, but the true effects of tamoxifen as an estrogen antagonist or agonist appear to depend on the background concentration of endogenous ligand (partial agonist at low estrogen concentration, for example,) (Paige et al., 1999)