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TFDP1 heterodimerizes with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes 57

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The BBB disruption, indicated by microhemorrhages [26], allows the entry of fibrinogen, plasma proteins, RBC, and other toxic substances into the brain parenchyma, further damaging neurons [233]

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Observed molecular and cellular responses are highly dependent on experimental conditions, concentration, exposure duration, and model system