Activating transcription factor 3 (ATF3) binds to the SLC7A11 promoter to inhibit System Xc- and promote Erastin-induced ferroptosis [48]
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Patients with sitosterolemia have mutations in either ABCG5 or ABCG8 and net absorption of dietary plant sterols is increased (20-30% absorbed vs
The effects of Cys, GSH, and MIX on Nrf2 signaling in ethanol-treated HepG2 cells were evaluated by qRT-PCR (Figure 7eg) and Western blotting (Figure 8)
All is good when the ROS produced in the mitochondria is converted appropriately into a non-reactive molecule, and ROS levels are kept in check
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