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It binds to GLP-1 receptors found on: Pancreatic -cells Stimulates glucose-dependent insulin secretion Pancreatic -cells Suppresses glucagon release during hyperglycemia Hypothalamic satiety centers Reduces appetite and food intake Gastrointestinal tract Delays gastric emptying, enhancing satiety This multi-site activity leads to improved glycemic control, reduced body weight, and cardiovascular benefits

Fortunately, these symptoms usually improve as the body adapts to treatment

Although some groups should avoid semaglutide, many patients are excellent candidates

Is it enough to just read the abstract

Epstein M, Sowers JR