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In addition, in the presence of the proteasome inhibitor BTZ, the degradation of EKR5 mediated by RNK06138 was significantly impaired, suggesting that RNK06138 induces the ubiquitin-mediated proteasomal degradation of ERK5 (Fig

Vitamin B6 in its less common form of pyridoxal 5-phosphate (PLP) may be less likely to cause neuropathy at high doses

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