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The role of SGLT2i in diabetic HFpEF SGLT2i, a class of the most recent anti-hyperglycemic drugs, have demonstrated beneficial effects on cardiovascular outcomes and played an important role in DM patients with HFpEF (Table 2)

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They enhance glucose metabolism, lower oxidative stress, and improve mitochondrial function, all of which safeguard telomeres and decrease the likelihood of health decline associated with aging