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GR (EC 1.6.4.2) activity was determined as NADPH oxidation recorded at 340 nm [26]

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Beyond GSH metabolism, Nrf2 also promotes intracellular NADPH generation by upregulating the expression of genes related to the pentose phosphate pathway, which contains the key enzyme G6PD, as well as genes involved in pyruvate cycling and folate metabolism (166)

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