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The earliest evidence of efficacy of ECP in pediatric aGvHD and cGvHD was reported in 2003 by Messina et al, 33 patients with aGvHD involving skin, liver and gut had CR in 76%, 60% and 75% respectively, and of 44 children with cGvHD, 15 (44%) showed a complete response and 10 (29%) a significant improvement after treatment (129)

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