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When AMP binds to the subunit, it allosterically activates the complex, making it a more susceptible substrate for phosphorylation at the threonine 172 site, which is more easily phosphorylated in the activation loop of the subunit by the primary upstream AMPK kinase LKB1

[2] Jastreboff AM, et al

He will be contesting a by-election, most likely on June 18th

doi: 10.7554/eLife.30916 430 NewbouldRDNicholasRThomasCLQuestRLeeJSHoneyfieldLet al

Although practical applications of NOD currently fall short from being clinically actionable, clinical trials are underway to stratify NOD patients with PDAC-associated diabetes

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