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If the pain does not respond to these treatments, or you lose movement or feeling, you may need surgery

A short breakdown of the receptor targets, signaling steps, and cellular effects reported in the peer-reviewed research literature

Nrf2 activation regulates antioxidant responses to modify cellular redox states from predominantly pro-oxidant to antioxidant, and, in an antioxidant environment, macrophage phenotypes shift from M1 pro-inflammatory to M2 anti-inflammatory, reducing the probability of cytokine storms, ARDS, and lethality (Tan et al., 2016