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Moreover, our study provides a mechanistic framework that could potentially explain other opioid-related side effects beyond constipation that may arise through modulation of central autonomic pathways (e.g., nausea, urinary retention, pruritus, and respiratory suppression) 41,42,43

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A: The serum is formulated with herbal extracts and is made from 100% natural ingredients

doi: 10.1136/archdischild-2023-326565 101

As a GLP-1 receptor agonist, it slows gastric emptying and potentially reduces stomach acid production