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While you need glutathione for a productive immune system, a weakened immune system hampers the production of glutathione

Furthermore, citicoline supplies the brain with choline and cytidine, which effectively inhibits the production of reactive oxygen species (ROS) in ischemia while simultaneously promoting the production and activity of antioxidants [82, 85]

Additionally, our molecular experiments confirmed that chemotherapy drugs increase the expression levels of intracellular GSH and antioxidant enzymes, leading to chemotherapy resistance during neoadjuvant chemotherapy

More globally, analysis of GPX4 protein expression levels performed in up to forty different cancers show that besides AML, GPX4 is also elevated in most hematological malignancies including Acute Lymphoblastic Leukemia (ALL), Multiple Myeloma (MM) and Non-Hodgkin's Lymphoma (NHL) [39]

Enteroviral 2B protein has been shown to interact with mitochondrial voltage-dependent anion channel 3 (VDAC3) to induce ROS production, and knockdown of VDAC3 significantly reduces EV71-induced mtROS generation and viral replication 132

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