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In many of the above studies, patients were reported to have subnormal B12 levels

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Third, they support the safety of repeated treatment cycles, as prior exposure does not appear to sensitize the immune system

This suggests that non-responders were less severely affected by ME/CFS at baseline, and that the main positive effect of nasal B12 administration occurs in more severely affected patients

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Diabetologia 58 (4), 799808