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420,421,422,423,424 The depletion of lactate catalyzed by LOx generates pyruvate, which in turn activates clustered regularly interspaced short palindromic repeat-associated protein 9 (CRISPR/Cas9)-mediated signal-regulatory protein alpha (SIRP) genome-editing plasmids

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Understanding this journey is not merely a pharmacokinetic exercise but is fundamental to explaining the disparate outcomes observed in clinical trials and for designing precision-based interventions

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