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High-quality clinical data from such studies will inform the development of clinical practice guidelines on HRT and MASLD, to guide counseling and informed decision-making for postmenopausal women and determine whether HRT has potential as a disease-modifying treatment for MASLD

A GIP agonist, ZP6590 (Zealand Pharma) is currently in a phase 1 trial, and a GLP-1/GIP antagonist, maridebart cafraglutide (formerly AMG 133, Amgen) is currently in phase 2 trials

Each membrane was rinsed three times for 15 min and incubated with the secondary antibodies (1:8000, Abcam, UK)

The experimental rats were placed in the plus-maze facing towards the open arm in the central arena of 10 cm and 5 min was allowed for each rat

The investigators employed in situ gelling microparticles encapsulating Lactiplantibacillus plantarum , a probiotic strain with well-documented wound-healing potential

First, its electrophilic carbon makes it a potent Nrf2 agonist that can induce the synthesis of key cellular antioxidants