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While the findings underscore spermidines potential as an agent for healthy aging, the underlying mechanisms and its effects on telomeres and longevity require further elucidation in human studies

(2) molecular dynamics simulated annealing restraining FOXO4 FH (without flexible regions) harmonically to its template structure (using a non-crystallographic force constant of 10,000 kcal mol 1 2 ), with additional dihedral angle restraints from 1 H, 15 N, and 13 C chemical shifts using TALOS-N 56 , hydrogen bond restraints (region p53 residues 48-55

In addition, the protective effect of ibuprofen containing nanoparticles on cytokine-induced barrier damage was also measured

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