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Look for: Texture changes: Thickened, rubbery, or spongy areas indicate early lipohypertrophy

However, another meta-analysis disputed this 50

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Although inflammation is typically mild, persistent, or severe cases warrant seeking medical advice to rule out potential infection or allergic reactions

Inform your prescriber about ALL medications and supplements you take, including over-the-counter products

Rotate injection sites among the abdomen, thigh, and upper arm to avoid repeated trauma to the same area