Zepbound, Mounjaro and liraglutide are part of the class of weight loss medications called GLP-1s, which have exploded in popularity in recent years
For the base cohort of new GLP-1 receptor agonist users, we excluded patients with a history of SGLT-2 inhibitors and vice versa for the base cohort of new SGLT-2 inhibitor users
all applicable states cover a non-weight-loss FDA indication such as the cardiovascular indication
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Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype
While it might not be the most glamorous topic, paying attention to these changes provides valuable feedback on how to adjust your fiber intake for optimal digestive health