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In different cell types, Nampt gene transcription is regulated by the circadian locomotor output cycles kaput/brain and muscle ARNT-like one (CLOCK:BMAL1) complex [38,198]

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A pilot study subsequently conducted by Holst in collaboration with Mette Zander at Hvidovre Hospital between September 1999 and October 2000 indicated that continuous subcutaneous infusions of synthetic GLP-1 over 6 weeks into patients with quite severe type 2 diabetes dramatically improved their blood sugar control, lowered glycated haemoglobin levels and decreased their body weight

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