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Various factors are involved in the progression of DN, such as disorder of oxygen metabolism and lipid metabolism, hyperglycemia, advanced glycosylation products, and inflammatory response [140, 141]

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Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of -cell failure

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Consequently, Nrf2 translocates into the nucleus and activates the transcription of many cytoprotective genes that encode detoxifying enzymes and antioxidant proteins, including NAD(P)H:quinone oxidoreductase 1, glutathione S -transferase, and heme oxygenase-1