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Life Sciences 27:15871591
Herbal diuretics (like Chanca Piedra) can assist in kidney detoxification
Theres also an important caveat about early treatment
doi: 10.1161/circulationaha.121.054360 Redd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yoshikawa, Yusuke, Chiu, Han Sheng, Gao, Ling, Hicks, Mark, Villanueva, Jeanette E., Joshi, Yashutosh, Chow, Chun Yuen, Cuellar-Partida, Gabriel, Peart, Jason N., See Hoe, Louise E., Chen, Xiaoli, Sun, Yuliangzi, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Xia, Di, Alzubaidi, Mubarak A
Mechanistically, BRD4770 inhibits mono-, di-, and tri-methylation of histone H3 at lysine 9 (H3K9me1/2/3), thereby reactivating key ferroptosis defense pathways, including the System Xc-GPX4 axis, the FSP1-CoQ10 axis, and the GTP cyclohydrolase 1 (GCH1)-BH4 pathway
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