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Shields JA, Eagle RC Jr, Shields CL, et al

The rapid growth of cancer cells leads to increased requirements for blood flow at the tumor site and the subsequent abnormal angiogenesis has been shown to compromise BBB integrity (204)

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For example, the HR for treatment discontinuation was 0.65 (95% CI 0.61, 0.68) for obesity class II/III vs normal weight (Table 2)