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The top ten molecules were chosen for experimental testing based on their binding energies and interaction with key binding site residues

Conversely, the release of inflammatory cytokines promotes the progression of ferroptotic cell death, such as the inhibition of GPX4 expression in tumour necrosis factor--treated cells (Fig

After hypoxic exposure, SOD and CAT mRNA expression in human fibroid cells was persistently suppressed compared to normal myometrial cells, suggesting an inherent impairment in the antioxidant machinery in uterine fibroids that may be further accentuated under hypoxia (Figure 2) [7]

Lastly, metformin treatment did not significantly alter the MDA increase and SOD decrease induced by MIA injection (OA model) in Nrf2 KO mice (Fig

Biochem J 298: 249258

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