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[7] Both metformin and GLP-1RAs are known to improve leptin sensitivity, making the brain more responsive to the anorexigenic effects of the adipokine

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Saneto, RP, Cohen, BH, Copeland, WC, Naviaux, RK 2013, Alpers-Huttenlocher Syndrome, Pediatric Neurology , vol

As representative molecular chaperones, HSPs can regulate conformational changes by promoting correct protein folding and refolding, repair denatured proteins, prevent misfolding, and maintain cellular homeostasis, thus protecting the host [14]