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Sirtuin 7 regulates nitric oxide production and apoptosis to promote mycobacterial clearance in macrophages

In schizophrenia, immune activation upregulates pro-inflammatory cytokines (e.g., IFN-, IL-1, TNF-), which activate indoleamine 2,3-dioxygenase (IDO) via both IFN- receptor (IFN-R)-dependent and independent pathways (e.g., synergistic action of TLR4, IL-1R, TNF-R) (215)

Beyond the necessity, we tested whether MAOB-dependent astrocytic GABA in the IL of PTSD-like mice is sufficient for impaired fear extinction retrieval within a PTSD context

[DOI] [PMC free article] [PubMed] [Google Scholar] 298.Himmerich H., Patsalos O., Lichtblau N., Ibrahim M.A.A., Dalton B